ADME is the process that drugs take effects at a molecule level once they are absorbed, and it’s the abbreviation of absorption, distribution, metabolism, and excretion, covering the whole course of drug taking effects in the bodies of human and rodent animals. Thus ADME Services will meet a wide range of related biochemical needs. Generally there are in vitro ADME services and in vitro services.
In vivo ADME services require higher on technologies and expertise, as live rodent animals like rats and dog will be involved, while the in vitro services put more stress on the equipment needed in the experiments.
Furtherly, ADME services are classified into two categories, ADME studies support and custom services. ADME studies like physicochemical studies work on the determination of drug molecule properties, including solubility, chemical stability, PMAPA Permeability, aiming to find out the performance of the test agent in any micro-circumstance, then contribute to the drug design process.
Rodent studies are a part of the ADME studies, designed to test the effect that drug will present on the carriers. Furthermore, bioequivalence studies are also under ADME studies, and they are settled to assess the biologically equivalent drug of the test agent.
ADME custom services consist of pharmacokinetic analysis of blood, metabolite isolation and characterization, bioavailability evaluations, formulation screening and optimization and etc. Pharmacokinetic analysis of blood is to observe the drug effect changes in blood with time variation, and all other services in this category is to better understand the drug properties and performance to present a better final drug with good treatment effect but less side effect and addiction.
ADME studies and services can help the pharmaceutical companies and related research labs from all sides by providing professional support and detailed information in vivo or in vitro from the absorption of drugs to the excretion, and finally assist them in probing more about the property and performance of a drug.